Climate changes in recent years have led to an increase in the average of global temperature and the occurrence of temperature anomalies. The research report shows that the increase in temperature resulting from climate change may reduce the yield of wheat by 5.5% globally. Heat stress has a negative effect on plant physiological processes such as photosynthesis, respiration, stomatal exchange, absorption of water and nutrients and it’s processing in the plant, as well as nitrogen metabolism, which leads to the limitation of photosynthetic resources and the reduction of biological and grain yield. Research shows that wheat cultivars show different reactions to these physiological changes and use different mechanisms such as heat shock proteins to withstand stress. Introduction of genotypes adapted to heat stress conditions is one of the important goals of breeding programs. The results of research in the past years show that selection based on physiological traits has increased the efficiency of breeding programs in order to produce genotypes adapted to heat stress. To explain the effectiveness of physiology knowledge in breeding programs based on target environments, it is necessary to explain the effect of stress on plant physiology, tolerance mechanisms and traits related to these mechanisms. Knowing about the physiological aspects of the plant in response to environmental stresses helps researchers to achieve high production potentials and introduce cultivars tolerant to adverse environmental conditions. In this research, the effect of heat stress on each of the physiological characteristics and different stages of growth and development of wheat has been investigated.