In order to study yield, dry matter accumulation, rate and duration of wheat grain filling in response to different levels of cycocel under soil salinity conditions, a factorial experiment was conducted based on randomized complete blocks design with three replications in research greenhouse of the Faculty of Agriculture, University of Mohaghegh Ardabili in 2015 cropping year. Under studied treatments including soil salinity at four levels (zero as control, 25, 50 and 75 milli Molar at soil) using NaCl and foliar application with cycocle at four levels (non-application, 400, 800 and 1200 milligram per liter). Results showed that with increasing soil salinity, yield, rate and duration of grain filling, root weight, total biomass and crop growth rate decreased. Means comparison showed that the maximum number of grains per spike (25.66), grain filling rate (1.48 gram per day), effective grain filling period (38.51 days), grain filling duration (42.21 days) and maximum grain weight (38.51 g) were obtained from foliar application of 1200 milligram per liter cycocel in non-application soil salinity conditions. Foliar application of 400, 800 and 1200 milligram per liter cycocel increased 8.86, 24.05 and 41.77 percent grain yield, respectively, compared to control. It seems that foliar application of 1200 milligram per liter of cycocel can be recommended to improve wheat yield in soil salinity conditions.